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. Author manuscript; available in PMC: 2019 Dec 26.
Published in final edited form as: Chem Rev. 2018 Oct 3;118(24):11519–11574. doi: 10.1021/acs.chemrev.8b00038

Figure 25.

Figure 25

De novo prion formation, cross-seeding and propagation in yeast. (a) Induction of the formation of a prion isoform ([PSI+]) of Sup35 protein by transient overproduction of Sup35 protein or its prion domain (PrD) is facilitated in the presence of a prion isoform ([PIN+]) of another protein, Rnq1, presumably due to a cross-seeding. Misfolded intermediate is indicated by a green ellipse, other designations are as on Figure 23. (b) Prion fragmentation and propagation by a chaperone machinery. Chaperone proteins are as designated (Hsp104 is a hexamer). Green rectangles indicate units of an amyloid fibril.