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. Author manuscript; available in PMC: 2019 Dec 26.
Published in final edited form as: Chem Rev. 2018 Oct 3;118(24):11519–11574. doi: 10.1021/acs.chemrev.8b00038

Figure 27.

Figure 27

Examples of amyloid structural models. (a) Het-s473. (b) Aβ42 478. (c) Amyloid core of a tau fibril470. Arrows indicate β-strands. Reprinted with permission from Wasmer, C.; Lange, A.; Van Melckebeke, H.; Siemer, A. B.; Riek, R.; Meier, B. H. Amyloid fibrils of the HET-s (218–289) prion form a β solenoid with a triangular hydrophobic core. Science 2008, 319, 1523–1526. Copyright 2008 American Association for the Advancement of Science. Reprinted with permission from Wälti, M. A.; Ravotti, F.; Arai, H.; Glabe, C. G.; Wall, J. S.; Böckmann, A.; Güntert, P.; Meier, B. H.; Riek, R. Atomic-resolution structure of a disease-relevant Aβ (1–42) amyloid fibril. Proc. Natl. Acad. Sci. U. S. A. 2016, 113, E4976-E4984. Copyright 2016 National Academy of Sciences. Reprinted with permission from Fitzpatrick, A. W. P.; Falcon, B.; He, S.; Murzin, A. G.; Murshudov, G.; Garringer, H. J.; Crowther, R. A.; Ghetti, B.; Goedert, M.; Scheres, S. H. W. Cryo-EM structures of tau filaments from Alzheimer’s disease. Nature 2017, 547, 185–190. Copyright 2017 Springer Nature.