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. Author manuscript; available in PMC: 2019 Dec 26.
Published in final edited form as: Chem Rev. 2018 Oct 3;118(24):11519–11574. doi: 10.1021/acs.chemrev.8b00038

Figure 4.

Figure 4

(a) Peptide assembly by classical nucleation. Monomers aggregate directly into structured assemblies and only assemblies above a critical size are propagated. (b) Peptide assembly by non-classical, two-step nucleation. Monomers first undergo liquid-liquid phase separation to form oligomeric particles, which then transition into structured assemblies. Reprinted with permission from Hsieh, M. C.; Lynn, D. G.; Grover, M. A. Kinetic Model for Two-Step Nucleation of Peptide Assembly. J. Phys. Chem. B 2017, 121, 7401–7411. Copyright 2017 American Chemical Society.