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. Author manuscript; available in PMC: 2019 Dec 26.
Published in final edited form as: Chem Rev. 2018 Oct 3;118(24):11519–11574. doi: 10.1021/acs.chemrev.8b00038

Table 5.

Examples of proven or proposed positive biological roles for amyloids and amyloid-like oligomers

Protein(s) Organism(s) Biological role in polymeric form Amyloid type
Het-s Fungus Podospora Vegetative incompatibility Switchable
Mot3 Yeast Multicellularity, ethanol resistance Switchable
Lsb2 Yeast Stress memory Switchable
Adhesins Fungi Substrate attachment, biofilm Inducible
CsgA,B (curli) Bacteria Substrate attachment, biofilm Inducible
Peptide hormones Mammals Storage Reversible
Pmel17 Animals Melanin synthesis Reversible
CPEB (Orb) Shellfish, flies, mice Long term memory Switchable
Silk/fibroin Spiders, insects Structure formation Constitutive