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At the top, 2D structures that represent the reaction of d-arabinose 5-phosphate (A5P) and phosphoenolpyruvate (PEP) to form 3-deoxy-d-manno-octulosonate-8-phosphate (KDO8P) and inorganic phosphate (Pi). The doubly phosphorylated intermediate (INT) is used as a reference for the design of the analog inhibitors: BPH1, BPH2, and BPH3.
