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. 2019 Jul 6;24(13):2482. doi: 10.3390/molecules24132482

Figure 8.

Figure 8

Proposed molecular mechanisms underlying the inhibitory effect of NAB on the LPS-activated RAW264.7 macrophages. NAB activates the Nrf2 pathway, leading to the high expression of HO-1, then contributing to the anti-inflammatory effects in LPS-activated RAW264.7 macrophages. Abbreviations in the figure: NAB, nardochinoid B; TLR4, Toll-like receptors; ERK, extracellular regulated protein kinase; JNK, c-Jun N-terminal kinase; HO-1, heme oxygenase (HO)-1; Nrf2, nuclear factor erythroid 2-related factor 2; Keap-1, Kelch-like ECH-associated protein-1; ARE, antioxidant response element; iNOS, inducible nitric oxide synthase; COX-2, cyclooxygenase-2; IKKα/β/γ, IκB kinase α/β/γ; IκBα, inhibitor of nuclear factor kappa-B kinase α.