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. 2019 Jul 24;39(30):6012–6030. doi: 10.1523/JNEUROSCI.2950-18.2019

Figure 4.

Figure 4.

Pvr is expressed in Class IV sensory neurons and is required for mechanical nociception. A, Pvr mRNA expression in Pvr mutants and control larvae. B, C, Behavioral responses to noxious mechanical pressures of 2346 kPa (B) and 5318 kPa (C) of indicated Pvr mutants and associated controls. D, E, Responses to noxious mechanical pressures of 2346 kPa (D) and 5318 kPa (E) of relevant genetic controls and larvae expressing UAS-PvrRNAi in class IV multidendritic sensory neurons. F, Pvr mRNA expression levels in relevant control larvae and larvae expressing UAS-PvrRNAi transgenes in class IV sensory neurons. G, Pvr expression in isolated class IV multidendritic sensory neurons expressing GFP. Red arrow indicates magnetic beads. G′, Cell fluorescence quantification. Box plots of total fluorescence represent median (horizontal line). Whiskers represent the 2.5th and 97.5th percentiles. C, F, Box plots represent median (horizontal line). Whiskers represent the 10th and 90th percentiles. Data are mean ± SEM. Statistical analysis was performed using two-tailed unpaired t test, one-way ANOVA with Dunnett's and Tukey's post hoc tests: *p < 0.05; **p < 0.01; ***p < 0.001.