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. 2019 Jul 24;39(30):6012–6030. doi: 10.1523/JNEUROSCI.2950-18.2019

Figure 7.

Figure 7.

Pvr-induced mechanical hypersensitivity is mediated by Piezo and Painless in Class IV sensory neurons. A, B, Quantitation of responses to noxious mechanical pressure (2346 kPa) of control larvae and indicated mutants and deficiencies for Piezo (A) and pain (B). C, D, Quantitation of responses to noxious mechanical pressure (2346 kPa) of relevant controls and ppk1.9-Gal4 expressing UAS-PiezoRNAi (C) and UAS-painRNAi (D). E, Genetic interaction between Pvr and piezo or Pvr and pain. F, H, Suppression of Pvr-induced mechanical allodynia (F) and hyperalgesia (H) by coexpression of either UAS-PiezoRNAi or UAS-painRNAi in class IV multidendritic sensory neurons. G, I, Suppression of Pvr-induced genetic mechanical allodynia (G) and hyperalgesia (I) in piezo and pain mutant larvae. Data are mean ± SEM. Two-tailed unpaired t test and one-way ANOVA with post hoc Tukey's test were used for statistical analyses: *p < 0.05; **p < 0.01; ***p < 0.001.