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. 2019 Jul 24;39(30):5935–5948. doi: 10.1523/JNEUROSCI.2904-18.2019

Figure 1.

Figure 1.

Chronic administration of metformin reverses HFD-induced glucose metabolism impairment. Two groups of mice were fed an HFD for 16 weeks and chronically treated with Met (300 mg/kg) or its Veh in the drinking water for the last 4 weeks. The control group of mice was fed an STD and administered the Veh. A–H, Data are the mean ± SEM of body weight from week 0 to week 16 (A), final body weight (F(2,27) = 10.4; p = 0.0004; B), fluid intake (C), basal fasting glycemia (F(2,27) = 23.9; p = 0.0001; D), basal fasting insulinemia (F(2,27) = 10.1; p = 0.0008; E), HOMA-IR (F(2,27) = 11.2; p = 0.0005; F), and glucose tolerance in response to the intraperitoneal administration of glucose (for AUC0–120: F(2,27) = 24.9; p = 0.0001; 2 g/kg; G, H). n = 10 mice/group. *p < 0.05 and ***p < 0.001: significantly different from the STD-Veh group. #p < 0.05 and ###p < 0.001: significantly different from the HFD-Veh group.