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Effects of fremanezumab on CSD-induced PPEEs. A, Example images of a PPEE occurring on the border of a dural blood vessel (red arrow). B, Representative image showing location of PPEEs (red circles) during CSD in one rat. C, Quantification of average frequency of PPEEs per 250 s bins (red) overlaid with a plot of average dural artery diameter (green) post-CSD. D, Quantification of the average number of PPEEs during CSD in rats injected with drug (red) and vehicle (blue).
