Table 3.
PQS in the HSV-2 and VZV IE promoter sequences. Each PQS is indicated by the 5′ nt position on the viral reference genome (NC_001798.2 and NC_001348.1). The leading and the lagging strands are indicated with respect to the TSS position. The conservation ratio (C (%)) of the entire sequence (G tracts and loops) among all the strains available in the NCBI databank is also indicated.
| HSV-2 | Leading Strand | Lagging Strand | C (%) |
|---|---|---|---|
| ICP0 | |||
| 1571 | GGGAAGCCGGCGCGGGGCGGTCGCCGGGGCGGAGTCCGGG | 100 | |
| 1913 | GGGGGCGGGCACCACTCAGGGCCGCGCCGGCGGGGCGCCGGGGGG | 100 | |
| 2027 | GGGGACGGGGCCGCCCCGAGAGGGGGGG | 100 | |
| ICP4 | |||
| 149044 | GGGGCGCGCGGGGCGGGGGG | 100 | |
| 149088 | GGGGCCGGCGGGGGCCAACGGGAGCGCGGGG | 100 | |
| 149287 | GCGGACGCGCGGGCGTCGGGGCGGGG | 100 | |
| 149570 | GGGGCGGCAGTGGGGGGGGGTGG | 100 | |
| ICP22/ICP47 | |||
| 132299 | GGGGGGCCGGGCCGGGGGGACGGG | 100 | |
| 132325 | GGGGGGACGGGCCGGGGGGACGGG | 100 | |
| 132988 | GGGCCCGGACGGGGGGCGGG | 100 | |
| ICP27 | |||
| 114386 | GGGGACGGCGGGGGCGGGGGCGGTGACGCCCGACGGGGAGGG | 100 | |
| 114579 | GGGGCTGGGATGGCGGGTGTCCTCCGAGGGGG | 100 | |
| VZV | Leading Strand | Lagging Strand | C (%) |
| ORF61 | |||
| 104021 | GGGGTCCGCCGGGCGCCCAGAAACCGGGGGGGGGTTATTTTCGGGGGGGGG | 100 | |
| 105081 | GGGCGGGCGACGGGCGGG | 100 | |
| ORF62/ORF63 | |||
| 109246 | GGGGAGGAAATATGCGGTCGAGGGGGGGG | 99 | |
| 109703 | GCGGTTTTATGGGGTGTGGGCGGG | ||
| 110410 | GGGTAAAATGGCAATGGGGGATTCCGGGGCGGGAGACCTTCGATTGGG | 100 | |
| ORF4 | |||
| 4278 | GGGTGCAGGTAAGCTTGTTTGGGG | 100 |