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. 2019 Jun 30;20(13):3214. doi: 10.3390/ijms20133214

Figure 2.

Figure 2

MCPIP1 deficiency exacerbates extravasation of fluorescein isothiocyanate (FITC)-dextran in the injured regions of the brains after 24 h reperfusion following MCAO. (A–D) Representative images of FITC-dextran extravasation in the brains from the MCPIP1–/– mice and their wild-type littermates underwent 2 h MCAO followed by 24 h reperfusion. (E) Measurement of fluorescence intensity in the ischemic tissue. The MCPIP1–/– mice had a significant increase in the leakage of FITC-dextran compared to their wild-type littermates after 2 h of MCAO and 24 h of reperfusion. Values represent mean ± SD, * p < 0.05 versus wild-type group. n = 6 per group. Scale bar, 25 µm.