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Optimization of lead compound 1-methylhydantoin (1-MHD). The hydrophobic moieties were selected from nonsteroidal anti-inflammatory drugs. The designed 1-MHD derivatives were ibuprofen conjugated 1-MHD (1), aspirin conjugated 1-MHD (2), indomethacin conjugated 1-MHD (3), and naproxen conjugated 1-MHD (4).
