Table 1.
Datasets considered in this study. Selected: The number of genes for which at least a high confidence interaction with any other gene is catalogued in the STRING database (see methods). G: Genomics; E: Epigenomics; T: Transcriptomics. ** major evidence; * minor evidence.
| Type of Evidence | Description | Subjects | Number of Genes | |||
|---|---|---|---|---|---|---|
| Initial | Selected | |||||
| ** | * | ** | * | |||
| G | SFARI [8]. | - | 404 | 1087 | 334 | 799 |
| G | Network diffusion-based prioritization of autism risk genes identifies significantly connected gene modules [7]. | - | ||||
| G | Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder [23]. | 15,954 | ||||
| G | Synaptic, transcriptional and chromatin genes disrupted in autism [24]. | 13,808 | ||||
| E | Case-control meta-analysis of blood DNA methylation and autism spectrum disorder [10]. | 1654 | 416 | 1444 | 272 | 955 |
| T | Gene expression profiling differentiates autism case- controls and phenotypic variants of autism spectrum disorders [25]. | 116 | 330 | 3045 | 256 | 2131 |
| T | Blood gene expression signatures distinguish autism spectrum disorders from controls [15]. | 285 | ||||
| T | Disrupted functional networks in autism underlie early brain mal-development and provide accurate classification. [26]. | 147 | ||||
| T | Gene expression in blood of children with autism spectrum disorder [27]. | 47 | ||||