Table 2.

The 13 genes that closely interact with the core genes of ASDs. |I|: Number of interactors; |Ic|: Number of interactors that are core genes; p: Hypergeometric probability of observing |Ic| in a hypergeometric experiment; G: Genomics; E: Epigenomics; T: Transcriptomics; ** major; * minor; 0: No evidence; SFARI score: “minimal evidence” (4), “hypothesized but untested” (5); other modules: Reference of gene-networks studies of ASDs in which the gene is mentioned. The total number of genes considered is equal to the interactome size: 12,739 genes.

Symbol	Description	|I|	|Ic|	|core|	p	G	E	T	SFARI Score	Other Modules
HCN4	hyperpolarization activated cyclic nucleotide gated potassium channel 4	4	2	334	3.97 × 10−3	*	*	0	-	-
DLGAP2	DLG associated protein 2	21	8	334	3.10 × 10−8	*	0	0	4	[18,21,22]
HCN2	hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2	4	1	334	1.01 × 10−1	*	0	0	-	-
UBC	ubiquitin C	1168	43	334	1.41 × 10−2	*	0	0	-	[20]
NLGN2	neuroligin 2	28	8	334	4.04 × 10−7	*	0	0	4	[18]
WDR37	WD repeat domain 37	2	2	334	6.85 × 10−4	0	0	*	-	-
MTMR2	myotubularin related protein 2	6	1	334	1.47 × 10−1	*	0	0	-	-
EPB41L1	erythrocyte membrane protein band 4.1 like 1	34	9	334	1.55 × 10−7	*	0	0	-	[21]
GABRA5	gamma-aminobutyric acid type A receptor alpha5 subunit	17	4	334	8.43 × 10−4	*	0	0	5	[21]
STX1A	syntaxin 1A	78	10	334	3.47 × 10−5	*	0	0	4	[20,21]
EPB41	erythrocyte membrane protein band 4.1	16	5	334	4.14 × 10−5	*	0	**	-	[20]
CACNA1F	calcium voltage-gated channel subunit alpha1 F	37	6	334	3.63 × 10−4	*	0	0	4	[21]
PRKCA	protein kinase C alpha	197	11	334	1.48 × 10−2	*	*	*	4	-

Collectively, we observed that a significant number of “core+13” genes emerged as associated with ASDs at epigenomics level (p = 2.63 × 10⁻⁴; hypergeometic test; Table 3) and at transcriptomics level; p = 1.22 × 10⁻³ hypergeometic test, Table 3).