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. 2019 Jul 9;20(13):3365. doi: 10.3390/ijms20133365

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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MBNL functions in RNA biogenesis, localization and stability. MBNL regulates alternative (orange boxes) splicing events, including cassette (e) exon, 5′ splice site, 3′ splice site, mutually exclusive exons, (i) intron retention [121,129] and alternative 3′ end formation by alternative cleavage and polyadenylation (pA) [122]. MBNL also regulates microRNA (miRNA) biogenesis [96], circular RNA (circRNA) formation [123], mRNA localization (horizontal arrow) [121] and increases mRNA stability (vertical arrow) [124]. All examples represent MBNL-mediated events and representative targeted RNAs are indicated.