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MBNL gene and ZnF structures. (A) Exonic structure and function of MBNL paralogs [135,148,149,150]. Exon enumeration is derived from previous studies [151]. ZnF1/2 and ZnF3/4–zinc finger domain pairs 1/2 and 3/4 respectively. NLS–nuclear localization signal. MBNL protein levels are shown as Low (bottom) and High (top) which trigger the indicated splicing events (black lines). (B) The structural model of MBNL1 zinc fingers (ZnF; blue) in complex with RNA (red) [152].
