Table 3.

Opportunities for future research.

1	The cellular and molecular mechanisms and the potential interplay of COX-2 derived PGs in control of energy metabolism and the development of obesity and insulin resistance.
2	The detailed mechanisms regarding the role of PGs and their receptors in the development of these COX-2 mediated phenomenon.
3	The therapeutive strategy to develop COX-2 targeting compounds which could boost energy expenditure without trigger COX-2-mediated inflammation
4	To dissect the role of COX-2 dependent and independent adaptive thermogenesis and their impact on energy homeostasis
5	Clinical application of selective COX-2 activator in prevention and treatment of NAFLD