Figure 2.

Exposure to ionizing radiation leads to robust changes in liver metabolomic and lipidomic profiles. Panel (A): Three dimensional PLS-DA plot showing separation of healthy NHPs (N = 8) from those who either survived (N = 18) or succumbed to radiation-induced (N = 14) tissue injury within 60 days. The prediction accuracy for 100 permutations yielded a p-value of 0.04. Panels (B and C): Relative abundance of significantly dysregulated metabolites and lipids in the three study groups, respectively.