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. 2019 Jul 17;10:1504. doi: 10.3389/fimmu.2019.01504

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Copyright © 2019 Dankers, Davelaar, van Hamburg, van de Peppel, Colin and Lubberts.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The chemokine receptor profile in memory CCR6+ Th shifts upon treatment with 1,25(OH)₂D₃. (A) Memory CCR6+ Th cells were sorted from treatment-naïve early RA patients and cultured for 3 days with or without 1,25(OH)₂D₃. RNA was isolated and used for microarray analysis. Log2 of fold change induced by 1,25(OH)₂D₃ treatment is shown for all chemokine receptors that were detected in the microarray data. (B) Changes in the chemokine receptor profile were verified using flow cytometry on memory CCR6+ Th cells sorted from healthy controls which were cultured for 3 days with or without 1,25(OH)₂D₃. Mean and SEM are given for 3 patients (A) or 5 healthy controls (B). MFI; mean fluorescent intensity, ^**p < 0.01, ^***p < 0.001.