Table 1.
Role of main miR candidates in DCM mechanisms and pathophysiology.
| miRs | Expression Pattern | Pathophysiological Role | Expression Sight |
|---|---|---|---|
| miR-1 [69,75] | Downregulated | Hypertrophy and oxidative stress | Cardiac and skeletal muscle |
| miR-1/206 [71] | Upregulated | Cardiomyocytes apoptosis | Cardiac muscle |
| miR-34a [71,74] | Upregulated | Cardiomyocytes apoptosis | Cardiac muscle |
| miR-133a [69] | Downregulated | Hypertrophy and oxidative stress | Cardiac and skeletal muscle |
| miR-195 [71] | Upregulated | Cardiomyocytes apoptosis | Cardiac muscle |
| miR-212 [71,73] | Upregulated | Hypertrophy and autophagic response | Cardiac and skeletal muscle |
| miR-221 [71,72] | Upregulated | Hypertrophy and autophagic response | Cardiac and skeletal muscle |
| miR-320 [71] | Upregulated | Cardiomyocytes apoptosis | Cardiac muscle |
| miR-373 [69] | Downregulated | Hypertrophy and oxidative stress | Cardiac muscle, endothelium |
| miR-378 [71] | Downregulated | Hypertrophy and oxidative stress | Cardiac muscle, endothelium |
| Upregulated | Cardiomyocytes apoptosis | Cardiac muscle | |
| miR-451 [69] | Upregulated | Cardiomyocytes hypertrophy | Cardiac muscle |