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. 2019 Jul 5;20(13):3310. doi: 10.3390/ijms20133310

Table 3.

Other molecules acting in the formation of TAMs in CC.

Source Name of Molecules Potential Mechanism
T cell IL-17
  1. Increasing the expression of IL-6 [72]

  2. Increasing the recruitment of monocytes [72]

IL-4 Promoting M2a subtype polarization by inducing a transcriptional factor KLF4 [73]
IL-10 Promoting M2c subtype polarization [44]
IL-4 and IL-10 Promoting M2a subtype polarization [74]
Seminal plasma Increasing the expression of COX2, PGE2, IL-6 in CC cells [75,76,77]
Anaerobic microenvironment Promoting M2 polarization by overexpressing Nrp-1 in CC cells [78]

The table shows the role of the molecules from T cell, seminal plasma and anaerobic microenvironment to the formation of TAMs. IL-17, interleukin 17; IL-6, interleukin 6; KLF4, Kruppel-like factor 4; IL-10, interleukin 10; COX2, cyclooxygenase-2; PGE2, prostaglandin E2; Nrp-1, neuropilin-1.