Table 3.
Source | Name of Molecules | Potential Mechanism |
---|---|---|
T cell | IL-17 | |
IL-4 | Promoting M2a subtype polarization by inducing a transcriptional factor KLF4 [73] | |
IL-10 | Promoting M2c subtype polarization [44] | |
IL-4 and IL-10 | Promoting M2a subtype polarization [74] | |
Seminal plasma | Increasing the expression of COX2, PGE2, IL-6 in CC cells [75,76,77] | |
Anaerobic microenvironment | Promoting M2 polarization by overexpressing Nrp-1 in CC cells [78] |
The table shows the role of the molecules from T cell, seminal plasma and anaerobic microenvironment to the formation of TAMs. IL-17, interleukin 17; IL-6, interleukin 6; KLF4, Kruppel-like factor 4; IL-10, interleukin 10; COX2, cyclooxygenase-2; PGE2, prostaglandin E2; Nrp-1, neuropilin-1.