. 2019 Jul 5;20(13):3310. doi: 10.3390/ijms20133310

Table 4.

Component Involved in the Switch from M2 to M1-like macrophages.

	Component	Potential Mechanism
Targeting the differentiation of TAMs	CD4⁺ Th1 cells	Promoting TAMs to secret costimulatory molecules and the expression of CCR7 [28]
Targeting the differentiation of TAMs	rIFN-γ	Promoting TAMs to produce a diffusible tumoricidal substance [107]

The table above shows the component involved in the switch from M2 to M1-like macrophages. TAMs, tumor-associated macrophages; rIFN-γ, recombinant human γ-interferon; Th1, 1-type helper T cells.