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. 2019 Jul 9;20(13):3359. doi: 10.3390/ijms20133359

Figure 2.

Figure 2

Pregnenolone synthesis in C20 and H295R cells. (A) There were no significant changes in basal pregnenolone production between C20 wt and TSPO knock down or knockout cells (-tri., without trilostane; n.s., no significance). (B) Pregnenolone synthesis in H295R steroidogenic cells, which was over 40 times higher in comparison to C20 cells under basal conditions, could be additionally upregulated in response to cAMP treatment (p < 0.001). (C) Treatment with various TSPO ligands had no effect on pregnenolone production in C20 microglia cells. (D) Basal pregnenolone production in C20 wt and KO cells was furthermore not affected by cAMP treatment.