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. 2019 Jul 9;20(13):3374. doi: 10.3390/ijms20133374

Table 3.

Molecule inhibitors of GLUT1.

Inhibitor IC50 (Ki), µM * Type of Inhibition Cell Type Reference
Flavones and Isoflavones
Genistein 10–15 mM (4–15) competitive HL60, CHO, RBC [114,115,171]
Myricetin (23) competitive HL60, CHO, RBC [114]
Quercetin (8–16) competitive HL60, CHO, RBC [114,171]
Morin (105) competitive HL60, CHO, RBC [114]
Rhamnetin (20) competitive HL60, CHO, RBC [114]
Isorhamnetin (5) competitive HL60, CHO, RBC [114]
Biochanin A (17) competitive HL60, CHO, RBC [114]
Lavendustin and Tyrphostins
Lavendustin A (10) competitive HL60, CHO, RBC [114]
Lavendustin B (15) competitive HL60, CHO, RBC [114]
Tyrphostin B44 (90) competitive HL60, CHO, RBC [114]
Tyrphostin B46 (20–45) competitive HL60, CHO, RBC [114,171]
Tyrphostin B48 (50) competitive HL60, CHO, RBC [114]
Tyrphostin B50 (45) competitive HL60, CHO, RBC [114]
Tyrphostin B56 (170) competitive HL60, CHO, RBC [114]
Tyrphostin AG879 (85) competitive HL60, CHO, RBC [114]
Tyrphostin A47 (115–160) noncompetitive HL60, CHO, RBC [114,171]
Other Tyrosine Kinase Inhibitors
Methyl 2,5- dihydroxycinnamate (150) noncompetitive HL60, CHO, RBC [114]
Gossypol 30 (7) noncompetitive HL60, CHO, RBC [173]
Methylxanthines
Pentoxifylline 4.7 mM (2.8) uncompetitive RBC [55]
Caffeine 10 mM (4.5) uncompetitive RBC [55]
Theophylline 14.4 mM (5.3) uncompetitive RBC [55]
Phloretin 40 RBC [55]
Other Polyphenols
Resveratrol 30 (122) noncompetitive HL60, U937, RBC [116]
NDGA 53–85 mM (4.5) noncompetitive HL60, U937, RBC [172]
Gossypol 30 (7) noncompetitive HL60, CHO, RBC [173]
Kaempferol 4 mixed MCF-7 [174]
Curcumin 19 mixed L929 [175]

* IC50: correspond to 50% of total inhibition in viability experiments; Ki: correspond to inhibition constant in transport experiments.