Table 3.

Molecule inhibitors of GLUT1.

Inhibitor	IC50 (Ki), µM *	Type of Inhibition	Cell Type	Reference
Flavones and Isoflavones
Genistein	10–15 mM (4–15)	competitive	HL60, CHO, RBC	[114,115,171]
Myricetin	(23)	competitive	HL60, CHO, RBC	[114]
Quercetin	(8–16)	competitive	HL60, CHO, RBC	[114,171]
Morin	(105)	competitive	HL60, CHO, RBC	[114]
Rhamnetin	(20)	competitive	HL60, CHO, RBC	[114]
Isorhamnetin	(5)	competitive	HL60, CHO, RBC	[114]
Biochanin A	(17)	competitive	HL60, CHO, RBC	[114]
Lavendustin and Tyrphostins
Lavendustin A	(10)	competitive	HL60, CHO, RBC	[114]
Lavendustin B	(15)	competitive	HL60, CHO, RBC	[114]
Tyrphostin B44	(90)	competitive	HL60, CHO, RBC	[114]
Tyrphostin B46	(20–45)	competitive	HL60, CHO, RBC	[114,171]
Tyrphostin B48	(50)	competitive	HL60, CHO, RBC	[114]
Tyrphostin B50	(45)	competitive	HL60, CHO, RBC	[114]
Tyrphostin B56	(170)	competitive	HL60, CHO, RBC	[114]
Tyrphostin AG879	(85)	competitive	HL60, CHO, RBC	[114]
Tyrphostin A47	(115–160)	noncompetitive	HL60, CHO, RBC	[114,171]
Other Tyrosine Kinase Inhibitors
Methyl 2,5- dihydroxycinnamate	(150)	noncompetitive	HL60, CHO, RBC	[114]
Gossypol	30 (7)	noncompetitive	HL60, CHO, RBC	[173]
Methylxanthines
Pentoxifylline	4.7 mM (2.8)	uncompetitive	RBC	[55]
Caffeine	10 mM (4.5)	uncompetitive	RBC	[55]
Theophylline	14.4 mM (5.3)	uncompetitive	RBC	[55]
Phloretin	40		RBC	[55]
Other Polyphenols
Resveratrol	30 (122)	noncompetitive	HL60, U937, RBC	[116]
NDGA	53–85 mM (4.5)	noncompetitive	HL60, U937, RBC	[172]
Gossypol	30 (7)	noncompetitive	HL60, CHO, RBC	[173]
Kaempferol	4	mixed	MCF-7	[174]
Curcumin	19	mixed	L929	[175]

* IC₅₀: correspond to 50% of total inhibition in viability experiments; K_i: correspond to inhibition constant in transport experiments.