Table 1.
Gene expression in DLD-1 cells. Up-regulated genes had a fold change (2(−∆∆Ct)) above 1, while down-regulated genes had a 2(−∆∆Ct) below 1. Only statistically significant genes are shown.
| Gene Symbol | Gene Name | p Value | Fold-Change 2(−∆∆Ct) | Up (↑)/Down (↓) Regulation | Function |
|---|---|---|---|---|---|
| ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase | <0.05 | 0.29 | ↓ | Positive Regulation of Apoptosis |
| BAK1 | BCL2 antagonist/killer 1 | <0.05 | 0.11 | ↓ | Pro-Apoptotic/Positive Regulation of Apoptosis |
| BCL2L10 | BCL2 like 10 | <0.001 | 0.19 | ↓ | Anti-Apoptotic |
| BCL2L2 | BCL2 like 2 | <0.05 | 0.07 | ↓ | Anti-Apoptotic |
| BID | BH3 interacting domain death agonist | <0.05 | 0.29 | ↓ | Pro-Apoptotic/Positive Regulation of Apoptosis |
| CASP14 | Caspase 14 | <0.001 | 0.19 | ↓ | Pro-Apoptotic/Positive Regulation of Apoptosis/Caspase |
| CD27 | CD27 molecule | <0.001 | 0.22 | ↓ | Pro-Apoptotic/Anti-Apoptotic/Negative Regulation of Apoptosis/Caspase inhibitor |
| CD40 | CD40 molecule | <0.001 | 0.22 | ↓ | Positive Regulation of Apoptosis |
| CD40LG | CD40 ligand | <0.05 | 0.25 | ↓ | Anti-Apoptotic |
| CD70 | CD70 molecule | <0.01 | 0.28 | ↓ | Pro-Apoptotic/Positive Regulation of Apoptosis |
| CIDEA | Cell death inducing DFFA like effector a | <0.01 | 0.17 | ↓ | Negative Regulation of Apoptosis/DNA Damage & Repair |
| IL10 | Interleukin 10 | <0.05 | 0.24 | ↓ | Anti-Apoptotic |
| LTBR | Lymphotoxin beta receptor | <0.001 | 0.10 | ↓ | Positive Regulation of Apoptosis |
| MCL1 | MCL1 apoptosis regulator, BCL2 family member | <0.01 | 0.10 | ↓ | Negative Regulation of Apoptosis |
| NAIP | NLR family apoptosis inhibitory protein | <0.001 | 5.69 | ↑ | Anti-Apoptotic/Negative Regulation of Apoptosis |
| NFkB1 | Nuclear factor kappa B subunit 1 | <0.01 | 3.09 | ↑ | Anti-Apoptotic |
| PYCARD | PYD and CARD domain containing | <0.01 | 0.28 | ↓ | Pro-Apoptotic/Positive Regulation of Apoptosis/Caspase Regulator |
| RIPK2 | Receptor interacting serine/threonine kinase 2 | <0.05 | 0.23 | ↓ | Anti-Apoptotic/Positive Regulation of Apoptosis |
| TNF | Tumor necrosis factor | <0.05 | 0.70 | ↓ | Death Domain Receptor/Anti-Apoptotic/Positive Regulation of Apoptosis |
| TNFRSF21 | TNF receptor superfamily member 21 | <0.01 | 284.18 | ↑ | Death Domain Receptor |
| TNFSF8 | TNF superfamily member 8 | <0.001 | 0.18 | ↓ | Pro-Apoptotic/Positive Regulation of Apoptosis |
| TP73 | Tumor protein p73 | <0.01 | 0.20 | ↓ | DNA Damage & Repair/Negative Regulation of Apoptosis |
| TRADD | TNFRSF1A associated via death domain | <0.05 | 0.09 | ↓ | Pro-Apoptotic/Positive Regulation of Apoptosis/Death Domain Receptor |