Table 2.
Gene expression in Caco-2 cells 24 h post-PDT. Up-regulated genes had a fold change (2(−∆∆Ct)) above 1, while down-regulated genes had a 2(−∆∆Ct) below 1. Only statistically significant genes are shown.
| Gene Symbol | Gene Name | p Value | Fold-Change 2(−∆∆Ct) | Up (↑)/Down (↓) Regulation | Function |
|---|---|---|---|---|---|
| AKT1 | AKT serine/threonine kinase 1 | <0.001 | 0.11 | ↓ | Anti-Apoptotic/Positive Regulation of Apoptosis |
| APAF1 | Apoptotic peptidase activating factor 1 | <0.01 | 0.21 | ↓ | Caspase Activator |
| BAD | BCL2 associated agonist of cell death | <0.01 | 0.29 | ↓ | Pro-Apoptotic/Positive Regulation of Apoptosis |
| BAK1 | BCL2 antagonist/killer 1 | <0.05 | 3.07 | ↑ | Pro-Apoptotic/Positive Regulation of Apoptosis |
| BAX | BCL2 associated X, apoptosis regulator | <0.001 | 0.24 | ↓ | Pro-Apoptotic/Anti-Apoptotic/Positive Regulation of Apoptosis/Caspase Activator |
| BCL2 | BCL2 apoptosis regulator | <0.001 | 0.22 | ↓ | Anti-Apoptotic/Negative Regulation of Apoptosis |
| BCL2L1 | BCL2 like 1 | <0.01 | 0.19 | ↓ | Anti-Apoptotic |
| BCL2L10 | BCL2 like 10 | <0.05 | 2.27 | ↑ | Anti-Apoptotic/Negative Regulation of Apoptosis |
| BCL2L11 | BCL2 like 11 | <0.05 | 2.27 | ↑ | Pro-Apoptotic |
| BIK | BCL2 interacting killer | <0.05 | 2.27 | ↑ | Pro-Apoptotic/Positive Regulation of Apoptosis |
| BIRC5 | Baculoviral IAP repeat containing 5 | <0.01 | 0.23 | ↓ | Anti-Apoptotic |
| BNIP2 | BCL2 interacting protein 2 | <0.05 | 0.38 | ↓ | Anti-Apoptotic/Negative Regulation of Apoptosis |
| CASP10 | Caspase 10 | <0.05 | 2.27 | ↑ | Positive Regulation of Apoptosis/Caspase |
| CASP14 | Caspase 14 | <0.05 | 2.27 | ↑ | Pro-Apoptotic/Positive Regulation of Apoptosis/Caspase |
| CASP2 | Caspase 2 | <0.001 | 0.19 | ↓ | Pro-Apoptotic/Positive Regulation of Apoptosis/Caspase |
| CASP6 | Caspase 6 | <0.001 | 0.53 | ↓ | Pro-Apoptotic/Positive Regulation of Apoptosis/Caspase |
| CASP8 | Caspase 8 | <0.01 | 0.34 | ↓ | Pro-Apoptotic/Positive Regulation of Apoptosis/Caspase |
| CD27 | CD27 molecule | <0.05 | 1.99 | ↑ | Pro-Apoptotic/Anti-Apoptotic/Negative Regulation of Apoptosis/Caspase inhibitor |
| CD40LG | CD40 ligand | <0.01 | 0.40 | ↓ | Anti-Apoptotic |
| CIDEA | Cell death inducing DFFA like effector a | <0.05 | 0.20 | ↓ | Negative Regulation of Apoptosis/DNA Damage & Repair |
| CYCS | Cytochrome c, somatic | <0.01 | 0.34 | ↓ | Pro-Apoptotic |
| DIABLO | Diablo IAP-binding mitochondrial protein | <0.001 | 7.82 | ↑ | Pro-Apoptotic |
| FADD | Fas associated via death domain | <0.05 | 0.18 | ↓ | Positive Regulation of Apoptosis/Death Domain |
| FASLG | Fas ligand | <0.01 | 0.23 | ↓ | Pro-Apoptotic/Positive Regulation of Apoptosis |
| GADD45A | Growth arrest and DNA damage inducible alpha | <0.03 | 0.58 | ↓ | Pro-Apoptotic |
| IGF1R | Insulin like growth factor 1 receptor | <0.001 | 0.13 | ↓ | Anti-Apoptotic/Negative Regulation of Apoptosis |
| LTBR | Lymphotoxin beta receptor | <0.01 | 0.42 | ↓ | Positive Regulation of Apoptosis |
| MCL1 | MCL1 apoptosis regulator, BCL2 family member | <0.01 | 2.27 | ↑ | Negative Regulation of Apoptosis |
| NAIP | NLR family apoptosis inhibitory protein | <0.05 | 2.27 | ↑ | Anti-Apoptotic/Negative Regulation of Apoptosis |
| PYCARD | PYD and CARD domain containing | <0.05 | 2.73 | ↑ | Pro-Apoptotic/Positive Regulation of Apoptosis/Caspase Regulator |
| RIPK2 | Receptor interacting serine/threonine kinase 2 | <0.01 | 2.28 | ↑ | Anti-Apoptotic/Positive Regulation of Apoptosis |
| TNF | Tumor necrosis factor | <0.05 | 2.27 | ↑ | Death Domain Receptor/Anti-Apoptotic/Positive Regulation of Apoptosis |
| TNFRSF10A | TNF receptor superfamily member 10a | <0.05 | 2.06 | ↑ | Pro-Apoptotic/Positive Regulation of Apoptosis/Death Domain Receptor |
| TNFRSF9 | TNF receptor superfamily member 9 | <0.05 | 2.27 | ↑ | Pro-Apoptotic/Positive Regulation of Apoptosis |
| TNFSF8 | TNF superfamily member 8 | <0.05 | 2.27 | ↑ | Pro-Apoptotic/Positive Regulation of Apoptosis |
| TP53 | Tumor protein p53 | <0.01 | 0.38 | ↓ | DNA Damage & Repair/Positive Regulation of Apoptosis/Caspase Activator |
| TP73 | Tumor protein p73 | <0.05 | 0.22 | ↓ | DNA Damage & Repair/Negative Regulation of Apoptosis |
| TRADD | TNFRSF1A associated via death domain | <0.05 | 0.32 | ↓ | Pro-Apoptotic/Positive Regulation of Apoptosis/Death Domain Receptor |