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. 2019 Jul 6;20(13):3325. doi: 10.3390/ijms20133325

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Ensemble cluster analysis of (a) unbound DBD(CCG1) and (b) CIA/ASF1-bound DBD(CCG1). Principal component analysis of (c) unbound DBD(CCG1) and (d) CIA/ASF1-bound DBD(CCG1). CIA/ASF1-bound DBD(CCG1) has two binding states, half-open state and open state, and the binding state changes are mainly caused by the movement of domain 1.