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. 2019 Jul 6;20(13):3325. doi: 10.3390/ijms20133325

Figure 7.

Figure 7

Ensemblecluster analysis of (a) F1536A, (b) V92A, and (c) Y112A. The mutation of F1536A does not lead to a binding state change, although its RMSD values show a large fluctuation. The mutations of V92A and Y112A make the conformation easier to change among the three states. Combining these with the angle analysis between two domains, it can be revealed that these two systems finally stay in the unbound closed binding state, while the wild type (WT) complex prefers to stay in the half-open state.