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. 2019 Jul 6;20(13):3328. doi: 10.3390/ijms20133328

Figure 3.

Figure 3

Post-translational Modifications and Regulators of NLRP3. NLRP3 is regulated via phosphorylation (P), ubiquitination (Ub), sumolyation (S), and s-nitrosylation (SN) through post-translational modifications. Post-translational modifications that positively affect NLRP3 activation are listed on the left and those that negatively act on NLRP3 to inhibit its activation are listed in the middle. Interacting partners of NLRP3 are listed on the right. ARIH2, ariadne homolog 2; BRCC3, BRCA1/BRCA2-containing complex subunit 3; FBX12, F-box/LRR-repeat protein 2; FBXO3, F-box only protein 3; JNK1, JUN N-terminal kinase 1; MAPL, mitochondrial-anchored protein ligase; MARCH7, membrane-associated RING finger protein 7; NO, nitric oxide; PKA, protein kinase A; PKD, protein kinase D; PP2A, phosphatase 2A; PTPN22, protein tyrosine phosphatase non-receptor 22; SENP6/7, sentrin/SUMO-specific proteases. GBP5, guanylate-binding protein 5; Hsp90, heat-shock protein 90; MARK4, microtubule-affinity regulating kinase 4; MIF, macrophage migration inhibitory factor; NEK7, NIMA-related kinase 7; PKR, double-stranded RNA-dependent protein kinase; STG1, suppressor of the G2 allele of skp1; TXNIP, thioredoxin-interacting protein.