PRR |
Pattern-recognition receptor |
PAMP |
Pathogen-associated molecular pattern |
DAMP |
Damage-associated molecular pattern |
PYD |
Pyrin domain |
NOD |
Nucleotide-binding oligomerization domain |
LRR |
Leucine-rich repeat |
NLR |
Nod-like receptor |
NLRP |
Nod-like receptor protein |
NLRP3 |
NLR family pyrin domain containing 3 |
NLRC4 |
NLR family CARD domain-containing protein 4 |
AIM2 |
Absent-in-melanoma 2 |
ASC |
Apoptosis-associated speck-like protein containing a caspase-recruitment domain |
IL |
Interleukin |
IFN |
Interferon |
GSDMD |
Gasdermin D |
CAPS |
Cryopyrin-associated periodic syndromes |
IL-1R |
IL-1 receptor |
MCC950 |
1-(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)-3-[4-(2-hydroxypropan-2-yl)furan-2-yl]sulfonylurea |
PtdIns4 |
Phosphatidylinositol-4-phosphate |
ATP |
Adenosine triphosphate |
TLR |
Toll-like receptors |
NF-κB |
Nuclear factor kappa-light-chain-enhancer of activated B cells |
MYD88 |
Myeloid differentiation primary response 88 |
TRIF |
TIR-domain-containing adapter-inducing interferon-β |
FADD |
Fas-associated protein with death domain |
LPS |
Lipopolysaccharide |
IRAK |
IL-1 receptor-associated kinase |
IKK |
Inhibitor of NF-κB kinase |
BRCC |
BRCA1-BRCA2-containing complex |
JNK |
c-Jun N-terminal kinase |
IRF1 |
Interferon regulatory transcription factor 1 |
mtDNA |
Mitochondrial DNA |
PLC |
Phospholipase C |
CL097 |
2-(ethoxymethyl)-3H-imidazo[4,5-c]quinolin-4-amine |
BAPTA-AM |
1,2-Bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid tetrakis(acetoxymethyl ester) |
NADPH |
Nicotinamide adenine dinucleotide phosphate |
GPCR |
G protein-coupled receptor |
CaSR |
Calcium-sensing receptor |
GPRC6A |
G protein-coupled receptor family C group 6 member A |
PIP2 |
Phosphatidylinositol 4,5-bisphosphate |
IP3 |
Inositol 1,4,5-triphosphate |
ER |
Endoplasmic reticulum |
IP3R |
IP3 receptor |
2APB |
2-aminoethoxy diphenylborinate |
P2RX7 |
P2X purinoceptor 7 |
TRPM |
Transient receptor potential ion melastatin |
TRPV |
Transient receptor potential ion vanilloid |
TXNIP |
Thioredoxin interacting protein |
MSU |
Monosodium urate |
VRAC |
Volume-related anion channel |
CLIC |
Chloride intracellular channel |
ROS |
Reactive oxygen species |
NOX2 |
NADPH oxidase 2 |
NOX4 |
NADPH oxidase 4 |
CPT1A |
Carnitine palmitoyltransferase 1A |
mtROS |
Mitochondrial ROS |
MAVS |
Mitochondrial antiviral-signaling protein |
TRAF3 |
TNF receptor associated factor 3 |
oxPAPC |
Oxidized phospholipid 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine |
GBP2 |
Guanylate-binding protein 2 |
IRGB10 |
Immunity-related GTPase family member b10 |
RIPK1 |
Receptor-interacting serine/threonine-protein kinase 1 |
CASP8 |
Caspase-8 |
DUB |
Deubiquitinating enzyme |
SCF |
Skp-Cullin-F box |
FBXL2 |
F-box L2 |
FBXO3 |
F-box O3 |
MARCH7 |
Membrane-associated RING-CH protein VII |
DRD1 |
Dopamine D1 receptor |
TRIM31 |
Tripartite Motif Containing 31 |
ARIH2 |
Ariadne homolog 2 |
USP |
Ubiquitin specific peptidase |
PKA |
Protein kinase A |
cAMP |
Cyclic AMP |
MAM |
Mitochondria-associated membrane |
DAG |
Diacylglycerol |
PTPN22 |
Protein tyrosine phosphatase, non-receptor type 22 |
PP2A |
Phosphotase 2A |
MAPL |
Mitochondrial-anchored protein ligase |
SENP |
Sentrin/SUMO-specific protease |
HSP90 |
Heat shock protein 90 |
SGT1 |
Suppressor of G2 allele of SKP1 |
TXNIP |
Thioredoxin-interacting protein |
GBP5 |
Guanylate-binding protein 5 |
PKR |
Double-stranded RNA-dependent protein kinase |
MIF |
Migration inhibitory factor |
MARK4 |
Microtubule-affinity regulating kinase 4 |
Nek7 |
NIMA-related kinase 7 |