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. 2019 Jun 29;20(13):3202. doi: 10.3390/ijms20133202

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Genetic deficiencies in mitophagy sensitize worms to UVC-induced neurodegeneration. For experiments, wild-type, pink-1 mutant, and pdr-1 mutant worms were exposed to UVC radiation on three consecutive days beginning at the L4 larval stage (Panel A). Neurodegeneration was then measured 24 h (Panel B), 48 h (Panel C), and 72 h (Panel D) following exposure. Scoring was performed as described in Methods: 0 represents no degeneration, while increasing numbers represent increasing severity of degeneration. Data shown are combined from three biological replicates with each treatment group comprising n > 30 worms scored for dendrites on each of 4 cephalic neurons for a total of >120 dendrites scored.