Figure 1.

CSE-derived H₂S regulates SP following CLP-induced sepsis. (a–d) Increased liver CSE expression (a) and quantification of CSE in ‘a’ (b), liver H₂S-synthesizing activity (c) and plasma H₂S levels (d) following CLP-induced sepsis. (e–g) Genetic deletion of CSE significantly decreased SP levels in liver (e), lung (f) and plasma (g) compared to WT mice following sepsis. Data represented as mean ± S.E.M. (n = 8). The significance of differences among groups was evaluated by ANOVA with post-hoc Tukey’s test. Statistical significance was assigned as p < 0.05 (* p < 0.05 vs. WT sham; # p < 0.05 vs. WT sepsis).