Figure 2.

CSE-derived H₂S regulates NK-1R following CLP-induced sepsis. (a–d) Genetic deletion of CSE significantly reduced liver (a) and lung (c) NK-1R protein expression compared to WT mice following sepsis and quantification of liver (b) and lung (d) NK-1R protein expression in ‘a’ and ‘c’, respectively. Data represented as mean ± S.E.M. (n = 8). The significance of differences among groups was evaluated by ANOVA with post-hoc Tukey’s test. Statistical significance was assigned as p < 0.05 (* p < 0.05 vs. WT sham; # p < 0.05 vs. WT sepsis).