Figure 3.

PPTA KO mice protect against sepsis-induced LSEC defenestration and gaps formation. (a,b) Representative images of liver sieve fenestration micrographs (a) and average gap area of liver sieve fenestrae (b). LSEC injury significantly increased (as evidenced by gaps formation) following CLP-induced sepsis in WT mice. Genetic deletion of PPTA in mice showed fewer gaps following sepsis compared to WT sepsis mice. Data represented as mean ± S.E.M. (n = 4). The significance of differences among groups was evaluated by ANOVA with post-hoc Tukey’s test. Statistical significance was assigned as p < 0.05 (* p < 0.05 vs. WT sham; # p < 0.05 vs. WT sepsis).