Table 1.
PPTA KO mice protect against sepsis-induced LSEC defenestration and gaps formation.
| Group | Diameter of Fenestrae (nm) |
Number of Fenestrae/µm2 |
Porosity (%) |
|---|---|---|---|
| WT Sham | 149.39 ± 12.40 | 10.63 ± 1.54 | 18.44 ± 2.18 |
| PPTA KO Sham | 135.83 ± 7.83 | 11.60 ± 2.56 | 17.64 ± 3.28 |
| WT Sepsis | 143.91 ± 9.04 | 6.40 ± 2.49 * | 11.05 ± 3.23 * |
| PPTA KO Sepsis | 144.68 ± 8.39 | 9.05 ± 0.94 | 15.71 ± 2.19 |
The liver sieve frequency and porosity was lower in septic WT mice, and native fenestration frequency and porosity in LSECs was preserved in mice with genetic deletion of PPTA. Data represented as mean ± S.E.M. (n = 4). The significance of differences among groups was evaluated by ANOVA with post-hoc Tukey’s test. Statistical significance was assigned as p < 0.05 (* p < 0.05 vs. WT sham).