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. 2019 Jul 17;10:798. doi: 10.3389/fphar.2019.00798

Figure 3.

Figure 3

RNA-seq reveals distinct expression pattern of miRNAs, lncRNAs, circRNAs, and mRNAs in HCT116 cells and QUE-treated HCT116 cells. (A–D) Volcano plot of DEmiRNAs, DElncRNAs, DEcircRNAs, and DEmRNAs expression profiles between HCT116 cells and QUE-treated HCT116 cells. (E-H) MA plot of DEmiRNAs, DElncRNAs, DEcircRNAs, and DEmRNAs expression profiles between HCT116 cells and QUE-treated HCT116 cells. (I–L) Unsupervised clustering analysis showing expression profiles of top 40 differentially expressed miRNAs, lncRNAs, circRNAs, and mRNAs between HCT116 cells and QUE-treated HCT116 cells. QUE-1, QUE-2, and QUE-3 represent three groups of HCT-116 cells treated with QUE. CON-1, CON-2, and CON-3 represent three groups of untreated HCT-116 cells. Abbreviation: QUE, quercetin. CON, control.