Table 3.
The top 20 up- and down-regulated miRNAs.
| Name | QUE-1 | QUE-2 | QUE-3 | CON-1 | CON-2 | CON-3 | P value | log2FC | Regulated |
|---|---|---|---|---|---|---|---|---|---|
| hsa-miR-219a-2-3p | 47.8313 | 38.034 | 41.278 | 0 | 0.3117 | 0.0359 | 9.24E−14 | 7.8505 | Up |
| novel_miR_20 | 10.7557 | 10.9283 | 23.3697 | 0.1065 | 0.1417 | 0.1435 | 2.33E−10 | 6.0999 | Up |
| hsa-miR-338-3p | 5.188 | 3.1838 | 5.3344 | 0 | 0 | 0.1793 | 2.87E−09 | 5.3058 | Up |
| novel_miR_710 | 110 | 1155.4 | 265.3222 | 5.1665 | 12.5832 | 8.141 | 0.01733 | 5.0431 | Up |
| hsa-miR-383-5p | 2.2777 | 1.4628 | 2.0321 | 0.1598 | 0 | 0 | 2.09E−08 | 4.8215 | Up |
| hsa-miR-30c-2-3p | 1.0123 | 1.0326 | 1.9051 | 0 | 0.1417 | 0 | 2.30E−07 | 4.1288 | Up |
| novel_miR_873 | 12.4007 | 22.8032 | 2.0321 | 0.1065 | 0.4534 | 0.7173 | 0.005265 | 4.0298 | Up |
| hsa-miR-433-3p | 4.6819 | 4.3885 | 3.4292 | 0.5326 | 0 | 0.0717 | 3.95E−07 | 3.9197 | Up |
| novel_miR_885 | 790.6 | 1696.2 | 3132.3 | 108.4427 | 88.5639 | 54.7634 | 0.000332 | 3.7825 | Up |
| hsa-miR-4485-3p | 3.5431 | 5.9374 | 16.3842 | 0.4261 | 0.6235 | 0.251 | 0.011976 | 3.6025 | Up |
| hsa-miR-1290 | 12.2742 | 57.8255 | 45.0883 | 2.024 | 2.2672 | 1.6139 | 0.000134 | 3.5209 | Up |
| hsa-miR-6797-3p | 1.0123 | 1.5489 | 1.5241 | 0.2131 | 0 | 0.0359 | 8.96E−09 | 3.5168 | Up |
| hsa-miR-504-5p | 11.2619 | 9.8957 | 11.4308 | 0.9055 | 0.9069 | 0.251 | 6.33E−05 | 3.4046 | Up |
| novel_miR_301 | 3.29 | 6.0235 | 8.3826 | 0.6392 | 0.3968 | 0.2869 | 6.23E−05 | 3.0738 | Up |
| hsa-miR-338-5p | 9.6169 | 10.6702 | 10.7958 | 0.9587 | 1.3603 | 0.251 | 0.000364 | 2.9959 | Up |
| novel_miR_841 | 2.0246 | 4.6467 | 3.4292 | 0.3728 | 0.4251 | 0.0359 | 3.64E−05 | 2.9880 | Up |
| novel_miR_684 | 334.9454 | 508.6404 | 1209.8 | 60.1335 | 69.8875 | 41.6374 | 0.007656 | 2.8662 | Up |
| hsa-miR-204-5p | 7.3392 | 6.6258 | 8.1286 | 0.6924 | 0.9352 | 0.7531 | 0.001859 | 2.5244 | Up |
| hsa-miR-125b-2-3p | 6.0738 | 2.4094 | 4.1913 | 0.9055 | 0.2834 | 0.3586 | 0.017467 | 2.5090 | Up |
| hsa-miR-5096 | 3.6696 | 2.4954 | 1.3971 | 0.2663 | 0.4534 | 0.1793 | 0.025683 | 2.4837 | Up |
| hsa-miR-1257 | 0 | 0.2581 | 0.381 | 3.1958 | 2.2672 | 5.3078 | 0.000527 | −4.9679 | Down |
| hsa-miR-143-3p | 167.4094 | 148.608 | 158.3804 | 222.4781 | 171.573 | 298.3478 | 0.046004 | −1.2611 | Down |
| hsa-miR-203a-3p | 1965.3 | 2110.8 | 2034.6 | 2944.9 | 3156.6 | 3924.2 | 0.004354 | −1.4364 | Down |
| hsa-miR-21-5p | 227730 | 184152 | 145194 | 259839 | 384154 | 139555 | 0.030963 | −1.0935 | Down |
| hsa-miR-26a-2-3p | 1.0123 | 1.1186 | 0.8891 | 2.0772 | 2.9191 | 5.4154 | 0.030104 | −2.5689 | Down |
| hsa-miR-33a-3p | 3.6696 | 3.0978 | 2.0321 | 5.6458 | 5.4697 | 6.4913 | 0.024884 | −1.6717 | Down |
| hsa-miR-3684 | 1.0123 | 1.2047 | 0.7621 | 2.1305 | 1.332 | 2.0801 | 0.030702 | −1.5871 | Down |
| hsa-miR-3942-5p | 1.5185 | 0.6884 | 0.254 | 1.8109 | 1.502 | 3.2277 | 0.035983 | −2.0560 | Down |
| hsa-miR-4454 | 8.9842 | 9.3794 | 2.9212 | 9.4275 | 22.1055 | 11.8349 | 0.021729 | −1.6904 | Down |
| hsa-miR-4484 | 0 | 0.6884 | 1.2701 | 1.4381 | 3.2025 | 1.5421 | 0.0045 | −2.4779 | Down |
| hsa-miR-451a | 18.2214 | 17.6402 | 18.4163 | 155.3671 | 117.6128 | 152.9216 | 5.91E−07 | −3.6597 | Down |
| hsa-miR-4671-3p | 0.3796 | 0.9465 | 0.508 | 1.4381 | 1.0486 | 2.2235 | 0.033673 | −2.1636 | Down |
| hsa-miR-486-5p | 16.5764 | 20.0496 | 31.2443 | 138.8024 | 117.3578 | 118.8514 | 1.12E−05 | −3.1721 | Down |
| hsa-miR-493-3p | 0.8858 | 1.6349 | 1.1431 | 2.0772 | 2.0122 | 2.4746 | 0.03867 | −1.5905 | Down |
| hsa-miR-6505-5p | 4.0492 | 1.9791 | 4.0643 | 7.6698 | 7.7653 | 4.8057 | 0.018848 | −1.6118 | Down |
| hsa-miR-7974 | 35.6836 | 83.2962 | 99.4482 | 491.8272 | 206.0634 | 370.2898 | 1.33E−05 | −3.0231 | Down |
| novel_miR_343 | 0.5062 | 1.1186 | 0.127 | 1.5979 | 1.0203 | 0.7531 | 0.029758 | −1.5914 | Down |
| novel_miR_379 | 11.3884 | 14.8006 | 11.9389 | 62.3173 | 20.6035 | 37.1904 | 0.00321 | −2.3063 | Down |
| novel_miR_895 | 1.645 | 2.4954 | 1.7781 | 7.8829 | 6.5466 | 9.5755 | 0.00074 | −2.7583 | Down |
QUE-1, QUE-2, and QUE-3 represent three groups of HCT-116 cells treated with QUE. CON-1, CON-2, and CON-3 represent three groups of untreated HCT-116 cells.
QUE, quercetin; CON, control.