Table 6.
The top 20 up- and down-regulated mRNAs.
| Gene Symbol | QUE-1 | QUE-2 | QUE-3 | CON-3 | CON-2 | CON-1 | P value | log2FC | Regulated |
|---|---|---|---|---|---|---|---|---|---|
| RP11-385D13.1 | 0.459 | 0.5438 | 0.1785 | 0.003 | 0 | 0 | 1.82E−12 | 7.9515 | Up |
| CTD-2410N18.5 | 40.0383 | 37.9792 | 2.5737 | 0.15 | 0.2501 | 1.9876 | 0.001324 | 4.4775 | Up |
| CXCL8 | 41.3213 | 20.8464 | 35.8399 | 1.6461 | 1.6596 | 2.5119 | 2.21E−08 | 3.9679 | Up |
| IL1RL1 | 0.4132 | 0.5353 | 0.9505 | 0.0603 | 0.0438 | 0.0062 | 1.53E−05 | 3.8184 | Up |
| EFCAB8 | 0.2146 | 0.4772 | 1.0995 | 0.0334 | 0.2802 | 0.0354 | 0.032473 | 3.7396 | Up |
| ACRC | 2.2348 | 1.6744 | 2.5938 | 0.3101 | 0.0706 | 0.273 | 1.27E−07 | 3.0842 | Up |
| PAPPA2 | 0.3623 | 0.3721 | 0.5551 | 0.0637 | 0.0413 | 0.0333 | 1.39E−05 | 3.0253 | Up |
| TUSC3 | 2.2369 | 3.4756 | 2.6733 | 0.1932 | 0.236 | 0.1381 | 8.89E−07 | 2.9856 | Up |
| EID3 | 7.5414 | 6.3091 | 1.5003 | 1.0693 | 0.3949 | 0.263 | 0.001709 | 2.9377 | Up |
| MMP1 | 4.5738 | 1.8258 | 1.8633 | 0.1547 | 0.5818 | 0.223 | 0.001026 | 2.7474 | Up |
| AADAC | 7.5793 | 4.7235 | 1.7104 | 1.4535 | 0.2833 | 0.2375 | 0.004429 | 2.7197 | Up |
| CYP4F3 | 12.0443 | 13.418 | 2.9752 | 1.8013 | 1.9014 | 0.9014 | 0.002971 | 2.7178 | Up |
| TCF19 | 0.6208 | 1.3387 | 0.4906 | 0.1369 | 0.1059 | 0.068 | 0.000219 | 2.6952 | Up |
| SLC6A12 | 0.3203 | 0.492 | 0.2143 | 0.1176 | 0.0204 | 0 | 0.004181 | 2.6693 | Up |
| C19orf38 | 2.3469 | 2.4262 | 4.4076 | 0.0535 | 0.3851 | 0.6403 | 0.001546 | 2.6459 | Up |
| DNAH12 | 0.1975 | 0.1442 | 0.0795 | 0.047 | 0.0126 | 0.0039 | 0.001165 | 2.6171 | Up |
| F2RL2 | 0.2827 | 0.6668 | 0.2137 | 0.2595 | 0.0422 | 0 | 0.004704 | 2.6124 | Up |
| LCT | 0.3575 | 0.5997 | 0.6578 | 0.0971 | 0.049 | 0.0792 | 0.000116 | 2.6094 | Up |
| TF | 2.1888 | 1.3499 | 0.1846 | 0.2799 | 0.061 | 0.1333 | 0.023651 | 2.5816 | Up |
| RP3-509I19.11 | 1.0911 | 1.3781 | 0.2671 | 0.1918 | 0.0291 | 0.1481 | 0.002571 | 2.5804 | Up |
| MAGEA6 | 0 | 0 | 0 | 1.724 | 0.7861 | 1.3604 | 6.11E−16 | #NAME? | Down |
| TNFSF12-TNFSF13 | 0 | 0.0017 | 0 | 0.6983 | 1.3414 | 1.0317 | 6.26E−13 | -9.1872 | Down |
| ANK1 | 0 | 0.0032 | 0.0038 | 0.1533 | 0.1184 | 0.1713 | 1.51E−08 | -5.8831 | Down |
| PRR15L | 0.1197 | 0.1226 | 0.0523 | 4.2384 | 6.2581 | 3.616 | 6.27E−15 | -5.8829 | Down |
| BAG6 | 0.0169 | 0.0162 | 0.0173 | 1.064 | 0.2955 | 1.0986 | 1.23E−05 | -5.7552 | Down |
| CD79B | 0.0782 | 0.0434 | 0 | 0.7712 | 1.9847 | 1.7625 | 2.56E−06 | -5.5688 | Down |
| KRT20 | 0.1982 | 0.0153 | 0 | 1.2966 | 1.2261 | 1.7863 | 1.50E−08 | -4.6740 | Down |
| HLA-DRB1 | 0.766 | 0 | 0 | 1.7502 | 7.4034 | 4.9431 | 0.000763 | -4.6398 | Down |
| AZGP1 | 0.0997 | 0 | 0.0493 | 0.7883 | 2.0076 | 1.042 | 8.16E−06 | -4.5796 | Down |
| TTYH1 | 0.1016 | 0.0395 | 0 | 0.6519 | 1.6136 | 0.4997 | 0.001463 | -4.5639 | Down |
| APOBEC3G | 0.0512 | 0 | 0.0447 | 0.4597 | 0.7297 | 0.6744 | 1.52E−06 | -4.4927 | Down |
| TNFRSF6B | 21.537 | 22.9604 | 25.2291 | 236.6955 | 496.5118 | 462.5763 | 1.58E−06 | -4.4295 | Down |
| PPP1R1B | 0.0538 | 0.0211 | 0.144 | 1.2598 | 1.2531 | 2.2257 | 1.90E−05 | -4.3329 | Down |
| S100A4 | 10.3514 | 11.3851 | 17.5961 | 152.9374 | 203.8127 | 277.9736 | 1.45E−06 | -4.3277 | Down |
| SMIM5 | 0.0333 | 0.1101 | 0.0115 | 0.8277 | 1.2896 | 0.4922 | 0.001183 | -4.3099 | Down |
| BST2 | 1.103 | 0.5154 | 1.395 | 7.6829 | 20.0847 | 14.3881 | 2.66E−05 | -4.0807 | Down |
| PTGDS | 0.1114 | 0.1319 | 0.0823 | 1.2747 | 1.8475 | 1.4403 | 8.25E−06 | -4.0613 | Down |
| TRIM29 | 0.015 | 0.0954 | 0.0401 | 0.6682 | 0.8271 | 0.6418 | 1.71E−07 | -4.0474 | Down |
| LRG1 | 0.1242 | 0.1033 | 0.2308 | 1.7433 | 1.6964 | 2.5503 | 2.71E−07 | -3.9326 | Down |
| CLIC3 | 0.5461 | 0.6195 | 2.4456 | 7.4547 | 23.1513 | 16.0411 | 0.000133 | -3.9134 | Down |
QUE-1, QUE-2, and QUE-3 represent three groups of HCT-116 cells treated with QUE. CON-1, CON-2, and CON-3 represent three groups of untreated HCT-116 cells.
QUE, quercetin; CON, control.