Table 4.
Combined genotype analysis for the VEGF polymorphisms 1451C>T, 1612G>A, and 1725G>A in RPL patients and controls.
| Combined Genotype | Controls (n = 236) | RPL Patients (n = 388) | AOR (95% CI) b | p a | p b |
|---|---|---|---|---|---|
| VEGF 1451C>T/VEGF 1612G>A | |||||
| CC/GG | 100 (42.6) | 178 (45.9) | 1.000 (reference) | ||
| CC/GA | 54 (22.8) | 62 (16.0) | 0.679 (0.437–1.055) | 0.085 | 0.333 |
| CC/AA | 12 (5.1) | 11 (2.8) | 0.550 (0.233–1.295) | 0.171 | 0.333 |
| CT/GG | 49 (20.7) | 106 (27.3) | 1.279 (0.841–1.946) | 0.250 | 0.333 |
| CT/GA | 12 (5.1) | 21 (5.4) | 0.937 (0.436–2.011) | 0.867 | 0.867 |
| CT/AA | 0 (0.0) | 0 (0.0) | N/A | N/A | N/A |
| TT/GG | 7 (3.0) | 10 (2.6) | 0.866 (0.318–2.358) | 0.779 | 0.867 |
| TT/GA | 2 (0.8) | 0 (0.0) | N/A | N/A | N/A |
| TT/AA | 0 (0.0) | 0 (0.0) | N/A | N/A | N/A |
| VEGF 1451C>T/VEGF 1725G>A | |||||
| CC/GG | 133 (56.5) | 221 (57.0) | 1.000 (reference) | ||
| CC/GA | 30 (12.7) | 30 (7.7) | 0.510 (0.290–0.898) | 0.020 | 0.020 |
| CC/AA | 3 (1.3) | 0 (0.0) | N/A | N/A | N/A |
| CT/GG | 58 (24.5) | 123 (31.7) | 1.275 (0.871–1.865) | 0.211 | 0.317 |
| CT/GA | 3 (1.3) | 4 (1.0) | 0.802 (0.176–3.652) | 0.776 | 0.776 |
| CT/AA | 0 (0.0) | 0 (0.0) | N/A | N/A | N/A |
| TT/GG | 9 (3.8) | 10 (2.6) | 0.698 (0.276–1.771) | 0.450 | 0.600 |
| TT/GA | 0 (0.0) | 0 (0.0) | N/A | N/A | N/A |
| TT/AA | 0 (0.0) | 0 (0.0) | N/A | N/A | N/A |
| VEGF 1612G>A/VEGF 1725G>A | |||||
| GG/GG | 153 (65.0) | 289 (74.5) | 1.000 (reference) | ||
| GG/GA | 3 (1.3) | 5 (1.3) | 0.178 (0.018–1.729) | 0.137 | 0.137 |
| GG/AA | 0 (0.0) | 0 (0.0) | N/A | N/A | N/A |
| GA/GG | 42 (17.7) | 61 (15.7) | 0.776 (0.497–1.210) | 0.263 | 0.263 |
| GA/GA | 24 (10.1) | 22 (5.7) | 0.472 (0.258–0.866) | 0.015 | 0.045 |
| GA/AA | 2 (0.8) | 0 (0.0) | N/A | N/A | N/A |
| AA/GG | 5 (2.1) | 4 (1.0) | 0.440 (0.116–1.670) | 0.228 | 0.409 |
| AA/GA | 6 (2.5) | 7 (1.8) | 0.627 (0.207–1.898) | 0.409 | 0.409 |
| AA/AA | 1 (0.4) | 0 (0.0) | N/A | N/A | N/A |
Abbreviations: RPL, recurrent pregnancy loss; AOR, adjusted odds ratio. a Fisher’s exact test. b False discovery rate-adjusted p-value for multiple hypotheses testing using the Benjamini–Hochberg method. Acceptance of statistical significance at p < 0.05 and 95% confidence interval not including 1. ORs and 95% confidence intervals of each specific genotype were calculated with reference to frequencies of all others.