Table 6.
Clinical variables in RPL patients, stratified by VEGF polymorphisms 1451C>T, 1612G>A, and 1725G>A status.
| Genotype | BUN (mg/dL) | Cr (mg/dL) | Total Cholesterol (mg/dL) | FBS (mg/dL) | Hct (%) | HDL (mg/dL) | LH (mIU/mL) | PT (sec) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mean ± SD | p a | Mean ± SD | p a | Mean ± SD | p a | Mean ± SD | p a | Mean ± SD | p a | Mean ± SD | p a | Mean ± SD | p a | Mean ± SD | p a | |
| VEGF 1451 C>T | ||||||||||||||||
| CC | 10.09 ± 2.83 | 0.412 | 0.72 ± 0.13 | 0.783 | 189.17 ± 48.91 | 0.874 | 95.84 ± 18.63 | 0.691 | 36.88 ± 3.89 | 0.032 | 53.72 ± 13.62 | 0.048 | 5.28 ± 10.97 | 0.880 | 11.52 ± 1.90 | 0.636 |
| CT | 9.60 ± 2.68 | 0.73 ± 0.12 | 185.58 ± 51.66 | 94.25 ± 14.26 | 35.74 ± 3.92 | 69.92 ± 18.10 | 5.37 ± 7.67 | 11.63 ± 1.25 | ||||||||
| TT | 10.9 ± 3.20 | 0.73 ± 0.10 | 181.25 ± 38.65 | 90.00 ± 10.98 | 36.63 ± 4.29 | N/A | 3.70 ± 2.13 | 12.08 ± 1.68 | ||||||||
| C allele | 9.93 ± 2.78 | 0.492 | 0.72 ± 0.12 | 0.933 | 187.96 ± 49.73 | 0.789 | 95.30 ± 17.26 | 0.542 | 36.51 ± 3.93 | 0.924 | 61.82 ± 17.63 | N/A | 5.31 ± 10.10 | 0.616 | 11.56 ± 1.70 | 0.423 |
| T allele | 10.9 ± 3.20 | 0.73 ± 0.10 | 181.25 ± 38.65 | 90.00 ± 10.98 | 36.63 ± 4.29 | N/A | 3.70 ± 2.13 | 12.08 ± 1.68 | ||||||||
| VEGF 1612 G>A | ||||||||||||||||
| GG | 9.83 ± 2.74 | 0.647 | 0.72 ± 0.12 | 0.957 | 192.37 ± 50.64 | 0.083 | 96.20 ± 18.81 | 0.431 | 36.53 ± 3.96 | 0.993 | 62.65 ± 16.58 | 0.758 | 4.91 ± 6.26 | <0.001 | 11.56 ± 1.42 | 0.003 |
| GA | 10.26 ± 3.05 | 0.72 ± 0.12 | 172.81 ± 43.00 | 92.88 ± 11.50 | 36.48 ± 3.95 | 59.66 ± 22.10 | 4.43 ± 2.56 | 11.34 ± 0.93 | ||||||||
| AA | 10.11 ± 2.12 | 0.71 ± 0.12 | 193.88 ± 51.47 | 91.89 ± 14.84 | 36.49 ± 3.81 | N/A | 19.40 ± 45.87 | 13.18 ± 5.47 | ||||||||
| G allele | 9.94 ± 2.82 | 0.859 | 0.72 ± 0.12 | 0.827 | 187.51 ± 49.46 | 0.723 | 95.35 ± 17.27 | 0.555 | 36.52 ± 3.95 | 0.982 | 61.82 ± 17.63 | 0.498 | 4.77 ± 5.48 | <0.001 | 11.50 ± 1.31 | 0.001 |
| A allele | 10.11 ± 2.12 | 0.71 ± 0.12 | 193.88 ± 51.47 | 91.89 ± 14.84 | 36.49 ± 3.81 | 59.66 ± 22.10 | 19.40 ± 45.87 | 13.18 ± 5.47 | ||||||||
| VEGF 1725 G>A | ||||||||||||||||
| GG | 9.81 ± 2.77 | 0.050 | 0.72 ± 0.13 | 0.596 | 189.77 ± 49.02 | 0.148 | 95.62 ± 17.85 | 0.314 | 36.51 ± 3.92 | 0.851 | 63.30 ± 16.99 | 0.148 | 4.79 ± 5.69 | 0.030 | 11.49 ± 1.34 | 0.035 |
| GA | 11.07 ± 2.75 | 0.73 ± 0.09 | 172.75 ± 51.15 | 91.62 ± 9.02 | 36.62 ± 4.12 | 36.70 ± 0.00 | 8.53 ± 23.69 | 12.43 ± 3.71 | ||||||||
| AA | N/A | N/A | N/A | N/A | 34.40 ± 0.00 | N/A | N/A | 11.40 ± 0.00 | ||||||||
| G allele | 9.95 ± 2.79 | 0.057 | 0.72 ± 0.12 | 0.034 | 187.80 ± 49.42 | 0.036 | 95.19 ± 17.15 | 0.017 | 36.52 ± 3.94 | 0.208 | 61.82 ± 17.63 | 0.245 | 5.26 ± 9.94 | 0.160 | 11.57 ± 1.70 | 0.326 |
| A allele | 11.07 ± 2.75 | 0.73 ± 0.09 | 172.75 ± 51.15 | 91.62 ± 9.02 | 36.53 ± 4.05 | 36.7 ± 0.00 | 8.53 ± 23.69 | 12.35 ± 3.57 | ||||||||
Abbreviations: RPL, recurrent pregnancy loss; PT, prothrombin time; BUN, blood urea nitrogen; Hct, hematocrit; HDL, high- density lipoprotein; LH, luteinizing hormone; Cr, creatinine; FBS, fasting blood sugar; SD, standard deviation. a Calculated using ANOVA; Calculated using the Kruskal-Wallis test.