Table 7.
Multiple linear regression analyses of clinical variables in Korean RPL patients according to the quintiles of clinical variables.
| Genotype | Homocysteine Decile (μmol/L) | BUN Decile (mg/dL) | Total Cholesterol Decile (mg/dL) | Hct Decile (%) | PLT Decile (103/μL) | aPTT Decile (sec) | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n = 276 | Coef | p | n = 192 | Coef | p | n = 173 | Coef | p | n = 200 | Coef | p | n = 200 | Coef | p | n = 206 | Coef | p | |
| VEGF 1451C>T | ||||||||||||||||||
| CC | 174 (63.0) | (ref) | 125 (65.1) | (ref) | 112 (64.7) | (ref) | 128 (64.0) | (ref) | 128 (64.0) | (ref) | 131 (63.6) | (ref) | ||||||
| CT | 95 (34.4) | −0.682 | 0.065 | 63 (32.8) | −0.409 | 0.360 | 57 (32.9) | −0.476 | 0.316 | 68 (34.0) | −1.058 | 0.014 | 68 (34.0) | −1.215 | 0.005 | 71 (34.5) | 0.171 | 0.692 |
| TT | 7 (2.5) | −0.296 | 0.787 | 4 (2.1) | 0.448 | 0.764 | 4 (2.3) | −0.366 | 0.804 | 4 (2.0) | −0.539 | 0.708 | 4 (2.0) | −0.156 | 0.918 | 4 (1.9) | −1.685 | 0.254 |
| Dominant (CC vs. CT+TT) | −0.656 | 0.067 | −0.358 | 0.414 | −0.469 | 0.311 | −1.029 | 0.014 | −1.156 | 0.006 | 0.072 | 0.865 | ||||||
| Recessive (CC+CT vs. TT) | −0.055 | 0.960 | 0.585 | 0.689 | −0.206 | 0.889 | −0.176 | 0.903 | 0.265 | 0.856 | −1.745 | 0.233 | ||||||
| VEGF 1612G>A | ||||||||||||||||||
| GG | 204 (73.9) | (ref) | 136 (70.8) | (ref) | 124 (71.7) | (ref) | 144 (72.0) | (ref) | 144 (72.0) | (ref) | 150 (72.8) | (ref) | ||||||
| GA | 63 (22.8) | 0.053 | 0.897 | 47 (24.5) | 0.271 | 0.581 | 41 (23.7) | −1.116 | 0.032 | 48 (24.0) | −0.080 | 0.867 | 48 (24.0) | −0.049 | 0.919 | 48 (23.3) | 0.955 | 0.044 |
| AA | 9 (3.3) | 1.927 | 0.048 | 9 (4.7) | 0.321 | 0.746 | 8 (4.6) | 0.298 | 0.776 | 8 (4.0) | −0.851 | 0.415 | 8 (4.0) | −0.132 | 0.901 | 8 (3.9) | −0.378 | 0.721 |
| Dominant (GG vs. GA+AA) | 0.288 | 0.466 | 0.279 | 0.543 | −0.885 | 0.070 | −0.190 | 0.674 | −0.061 | 0.894 | 0.765 | 0.092 | ||||||
| Recessive (GG+GA vs. AA) | 1.914 | 0.049 | 0.251 | 0.799 | 0.576 | 0.584 | −0.831 | 0.421 | −0.120 | 0.909 | −0.610 | 0.560 | ||||||
| VEGF 1725G>A | ||||||||||||||||||
| GG | 250 (90.6) | (ref) | 171 (89.1) | (ref) | 153 (88.4) | (ref) | 182 (91.0) | (ref) | 182 (91.0) | (ref) | 188 (91.3) | (ref) | ||||||
| GA | 26 (9.4) | 0.742 | 0.211 | 21 (10.9) | 1.392 | 0.037 | 20 (11.6) | −1.019 | 0.140 | 18 (9.0) | −0.220 | 0.756 | 18 (9.0) | −0.477 | 0.504 | 18 (8.7) | 1.260 | 0.077 |
| AA | 0 (0.0) | N/A | N/A | 0 (0.0) | N/A | N/A | 0 (0.0) | N/A | N/A | 0 (0.0) | N/A | N/A | 0 (0.0) | N/A | N/A | 0 (0.0) | N/A | N/A |
| Dominant (GG vs. GA+AA) | 0.742 | 0.211 | 1.392 | 0.037 | −1.019 | 0.140 | −0.220 | 0.756 | −0.477 | 0.504 | 1.260 | 0.077 | ||||||
| Recessive (GG+GA vs. AA) | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | ||||||
Abbreviations: RPL, recurrent pregnancy loss; PLT, platelet; aPTT, activated partial thromboplastin time; BUN, blood urea nitrogen; Hct, hematocrit; SD, standard deviation; Coef, regression coefficients; Ref, reference.