Figure 1.

Schematic diagram of the LGALS13 gene and its mRNA variants. Top—The exons and introns are marked by boxes and lines, respectively. Lower panels represent the mRNA and the protein coding region. The wild type Gal-13 (PP13) consists of four full exons. The truncated Gal-13 variant delT₂₂₁ is missing part of exon 3 and the full exon 4, while the Dex-2 variant is missing exon 2. The two variants—the truncated delT₂₂₁ variant and the spliced variant Dex-2 are both naturally occurring variants along with the promoter polymorphic variant of -98 A/C.