Table 1.
Species | Gal 10 Eosinophils |
Gal 13 Placenta |
Gal 14 Placenta |
Gal 16 Placenta |
Gal 17 Placenta |
Gal 20 Placenta |
Count | Invasion Level |
---|---|---|---|---|---|---|---|---|
Chimpanzee | 2 | 3+ | ||||||
Orangutan | 10A | 17C | 4 | 2+ | ||||
Baboon | 1 | 1+ | ||||||
Human | 10A | 17A 17B |
5 (with 2 subtypes of Gal 17) | 4+ | ||||
Gorilla | 1 | 3+ | ||||||
Colobus | 1 | 1+ | ||||||
Macaque | 17C | 4 | 2+ | |||||
Marmoset | 10A 10B 10C |
4 (with 3 subtypes of Gal 10) | 2+ | |||||
Sp. Monkeys | 10A 10B 10C |
4 (with 3 subtypes of Gal 10) | 2+ | |||||
Total species # | 4 | 8 | 5 | 4 | 3 | 2 |
The presence of placental galectins in primate placenta is provided following the analysis of the evolutionary differentiation tree [31,32,36,39,115] with the exception of Galectin 10 (Gal 10) that is generated in bone-marrow but reaches the placenta via its expression in white blood cells. The letters A, B, and C reflect isoforms of the molecules. In terms of invasion: gorilla, chimpanzee, and human species have the deepest trophoblast invasion (3+ and 4+) reaching the inner myometrium [114,115,116,117,118,119,120]. The others have a much shallower implantation (1+ or 2+). The color code indicates in which species the Gal isoforms are expressed. The numbers in “total” refer to the numbers of species in which a specific Gal isoform is expressed. The numbers in “Count” refer to the numbers of Gal isoforms expressed in a given species.