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. 2019 Jul 3;20(13):3278. doi: 10.3390/ijms20133278

Figure 1.

Figure 1

Gene expression machinery under hypoxia. Hypoxic conditions trigger transcription and splicing to induce expression of gene sets required for hypoxic adaptation. HIF: Hypoxia-Inducible Factor, NF-κB: nuclear factor-kappa B, CREB: cAMP-response Element-binding Protein, Nrf: NF-E2-related factor, STATs: signal transducers and activators of transcription, SRps: serine-arginine-rich (SR) proteins, Clks, Cdc2-like kinases.