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. 2019 Jul 6;20(13):3329. doi: 10.3390/ijms20133329

Figure 2.

Figure 2

(A) Translation of premature termination codon (PTC)-containing mRNA in the absence of translational readthrough-inducing drugs (TRIDs); (B) ideal readthrough of PTC; (C) readthrough inserting a cognate amino acid; and (D) readthrough skipping amino acid insertion. Figure legend: mRNA, RNA messenger; tRNA, RNA transfer; 40S and 60S, small and large ribosome subunit, respectively; eEF1A, eukaryotic translation elongation factor 1A; eRF1 and eRF3, eukaryotic translation termination factor 1 and 3, respectively; and GTP, guanosine-5’-triphosphate.