Figure 4.

Chronic periodontitis (ChP) treatment reverses aspects of the systemic immune manifestations of ChP. (A) Box plot depicting the cell signaling–based elastic net (csEN) model values in samples from patients with ChP and controls in the treatment cohort, before and after ChP treatment. The csEN values are increased in samples from patients with ChP before treatment as compared with controls (9 patients, 7 controls, Wilcoxon rank sum test P = 7.9E-3) but not after treatment. Values are presented as median, interquartile range, and range. (B, C) csEN model component values overlaid on the immune signaling network for the patients who underwent scaling and root planing (n = 9) or prophylactic cleaning (n = 7). Nodes are colored by the median difference in signaling activity (arcsinh transform) between patients with ChP and controls. The size of the nodes varies according to the P value (Wilcoxon rank sum test, 1-tailed). (B) Before treatment. (C) After treatment.