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Aging coefficients reflect increases in late-onset disease (LOD) liability with age, based on the clinical incidence rate and model genetic architecture polygenic risk score (PRS). (A) Alzheimer’s disease (AD), (B) type 2 diabetes (T2D), (C) cerebral stroke, (D) coronary artery disease (CAD), (E) breast cancer, (F) prostate cancer, (G) colorectal cancer, and (H) lung cancer.
