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. 2019 Jul 7;20(13):3335. doi: 10.3390/ijms20133335

Figure 1.

Figure 1

Chemical shift (CS)-Rosetta de novo structural generation for phosphoprotein enriched in astrocytes-15 kDa (PEA-15) in free and extracellular signal-regulated kinase 2 (ERK2)-bound form. (A) Plot of Rosetta energy versus Cα root-mean-square deviation (RMSD) for the free form. (B) Plot of Rosetta energy versus Cα RMSD for the ERK2-bound form. (C) Lowest energy structure of PEA-15 in free form. (D) Lowest energy structure of PEA-15 in ERK2-bound form. (E) Ramachandran plot for free-form PEA-15. (F) Ramachandran plot for the ERK2-bound PEA-15. Both Ramachandran plots show 98.9% of residues in a favored region (black dots), 1.1% in an allowed region (orange dots), and no residues in a disallowed region.